PT - JOURNAL ARTICLE AU - Brown, Anthony AU - Jenkins, Laura AU - Reid, Alastair AU - Leavy, Anne AU - McDowell, Glen AU - McIlroy, Claire AU - Thompson, Andrew AU - McNaughten, Ben TI - How to perform and interpret the sweat test AID - 10.1136/archdischild-2018-316615 DP - 2020 Aug 01 TA - Archives of disease in childhood - Education & practice edition PG - 230--235 VI - 105 IP - 4 4099 - http://ep.bmj.com/content/105/4/230.short 4100 - http://ep.bmj.com/content/105/4/230.full SO - Arch Dis Child Educ Pract Ed2020 Aug 01; 105 AB - Cystic fibrosis (CF) is the most common life-threatening autosomal-recessive disease affecting Caucasians in the western world. The sweat test is the main diagnostic test for CF. It is indicated as part of the clinical assessment for infants that have picked up on the national neonatal screening programme. It may also be requested where clinical suspicion of a diagnosis of CF exists despite normal screening results. This article outlines the physiological basis behind sweat testing and the technical aspects of performing the test. Indications for performing the test are also considered. The article aims to provide clinicians with a guide to interpretation of results.