Footnotes

• Twitter @dremilyprior, @DrCGale

• Contributors EP and CG planned the manuscript. EP wrote the manuscript, supervised by SNU and CG. All authors contributed to the final version of the manuscript.

• Funding EP received support from a clinical research training fellowship from the Medical Research Council and Chelsea and Westminster Medical Research Charity. CG received support from the UK Medical Research Council through Clinician Scientist Fellowship and Transition Support awards and from Chiesi Pharmaceuticals to attend an educational conference; in the past 5 years, he has been investigator on received research grants from Medical Research Council, National Institute of Health Research, Canadian Institute of Health Research, Department of Health in England, Mason Medical Research Foundation and Westminster Medical School Research Trust and Chiesi Pharmaceuticals. SNU declares no funding nor conflicts of interest in relation to the work submitted.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.